Related Experiment Video
Updated: May 19, 2026
10:04
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Evolving therapeutic paradigms for multiple myeloma: back to the future
Benjamin M Cherry1, Neha Korde, Mary Kwok
1Multiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Leukemia & Lymphoma
|August 14, 2012
Summary
The treatment of multiple myeloma (MM) has evolved from early chemotherapy to high-dose therapy with stem cell transplant. Novel agents now offer comparable efficacy as frontline therapy, challenging previous paradigms.
Area of Science:
- Hematology
- Oncology
- Clinical Therapeutics
Background:
- Multiple myeloma (MM) treatment has historically lacked effective therapies.
- Early treatments like melphalan and prednisone improved survival but were limited.
- The development of high-dose therapy with autologous stem cell transplant (HDT-ASCT) marked a significant advancement.
Purpose of the Study:
- To review the historical evolution of therapeutic strategies for multiple myeloma.
- To discuss the impact of various treatments on patient survival and remission duration.
- To explore emerging treatment paradigms and future research directions in MM.
Main Methods:
- Review of historical therapeutic approaches for multiple myeloma.
- Analysis of treatment outcomes including survival and remission rates.
- Discussion of the paradigm shift from extended dosing to intensive therapy and maintenance strategies.
Main Results:
- Melphalan and prednisone initially tripled survival, becoming a standard of care.
- HDT-ASCT improved remission duration and survival but relapse remained common.
- Novel agents have shown efficacy in maintenance therapy and as frontline treatment, challenging the HDT-ASCT paradigm.
Conclusions:
- Therapeutic strategies for multiple myeloma have advanced significantly over decades.
- Novel agents are reshaping the treatment landscape, offering new options for frontline and maintenance therapy.
- Future research is crucial to address remaining challenges and optimize MM treatment.
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