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Updated: May 19, 2026
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3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
Published on: December 9, 2014
A mathematical model for within-host Toxoplasma gondii invasion dynamics
Adam Sullivan1, Folashade Agusto, Sharon Bewick
1Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, United States. asulli17@utk.edu
Mathematical Biosciences and Engineering : MBE
|August 14, 2012
Summary
Toxoplasma gondii (T. gondii) infection dynamics within a host are modeled mathematically. This model aids in understanding parasite invasion, replication, and host immune responses to T. gondii.
Area of Science:
- Parasitology
- Mathematical Biology
- Immunology
Background:
- Toxoplasma gondii (T. gondii) is a widespread protozoan parasite infecting mammals and birds.
- Chronic T. gondii infection affects 20% of the US and 30% of the global human population.
Purpose of the Study:
- To develop a mathematical model simulating intra-host T. gondii infection dynamics.
- To analyze the impact of various parameters on infection progression and host immune response.
Main Methods:
- Development of a mathematical model incorporating parasite invasion, egress, and stage interconversion (tachyzoite/bradyzoite).
- Inclusion of host immune response mechanisms within the model.
- Analytical and numerical simulations to study model behavior.
Main Results:
- The model captures key aspects of T. gondii intra-host dynamics, including replication and immune interaction.
- Simulations reveal how different parameters influence transient and steady-state infection levels.
- Insights into the complex interplay between parasite stages and host immunity.
Conclusions:
- The mathematical model provides a framework for understanding T. gondii pathogenesis.
- Further analysis can elucidate critical factors governing infection severity and persistence.
- This approach can inform strategies for managing T. gondii infections.
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