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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Updated: May 19, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

"Flow valve" microfluidic devices for simple, detectorless, and label-free analyte quantitation.

Debolina Chatterjee¹, Danielle S Mansfield, Neil G Anderson

¹Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA.

Analytical Chemistry

|August 14, 2012

Summary

We created portable microfluidic devices for simple visual concentration measurement. These "flow valve" systems detect targets like streptavidin down to 1 ng/mL without complex instruments.

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Last Updated: May 19, 2026

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Fluorescence detection methods for microfluidic droplet platforms

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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

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Published on: October 15, 2013

Area of Science:

Biotechnology
Microfluidics
Analytical Chemistry

Background:

Portable analysis systems offering benchtop performance are in high demand.
Current portable systems often require complex detection instrumentation.
There is a need for simplified, visually-read analytical devices.

Purpose of the Study:

To develop novel, miniature devices for visual concentration readout.
To enable quantitation using microfluidic channels and visual inspection.
To demonstrate the utility of these devices for sensitive target detection.

Main Methods:

Constructing microchannels within an elastomeric material.
Coating channel surfaces with specific receptors.
Introducing a sample solution and measuring flow distance before flow stops due to target-induced channel constriction.

Main Results:

Developed "flow valve" systems with visual inspection readout.
Quantitation achieved by measuring flow distance in microfluidic channels.
Detected streptavidin concentrations as low as 1 ng/mL.
Flow distance scales with the negative logarithm of target concentration.

Conclusions:

The developed devices offer a simple, portable method for quantitative analysis.
Visual inspection readout eliminates the need for complex detection instrumentation.
These "flow valve" systems are attractive for various analytical applications.