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Related Experiment Video

Updated: May 19, 2026

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS
11:02

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Published on: May 12, 2011

Transposition surgery for internuclear ophthalmoplegia.

Niraj R Nathan, Sean P Donahue

    Journal of Pediatric Ophthalmology and Strabismus
    |August 14, 2012
    PubMed
    Summary
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    Extraocular muscle transposition surgery effectively corrects exodeviation in patients with internuclear ophthalmoplegia. This procedure, especially when combined with lateral rectus recession, significantly reduces eye deviation and improves alignment.

    Area of Science:

    • Ophthalmology
    • Surgical Techniques
    • Neuro-ophthalmology

    Background:

    • Internuclear ophthalmoplegia (INO) often presents with significant exodeviation and limited adduction.
    • Surgical correction aims to improve ocular alignment and binocular function in INO patients.

    Purpose of the Study:

    • To evaluate the outcomes of extraocular muscle transposition surgery for correcting exodeviation in internuclear ophthalmoplegia.

    Main Methods:

    • Retrospective review of five patients with INO undergoing extraocular muscle transposition between 1999 and 2011.
    • Preoperative and postoperative orthoptic evaluations assessed deviation, motility, and visual acuity.

    Main Results:

    • A mean exodeviation reduction of 59 prism diopters (99.6%) was achieved.

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    Last Updated: May 19, 2026

    Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS
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    Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

    Published on: May 12, 2011

    Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
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  • Four out of five patients attained orthotropia in primary gaze post-surgery.
  • One patient required additional lateral rectus recession for residual exodeviation.

    • Conclusions:

    • Extraocular muscle transposition is an effective surgical option for INO with exodeviation.
    • Combining transposition with ipsilateral lateral rectus recession enhances outcomes for INO patients.