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Rectal lymphoma in 11 dogs: a retrospective study.
N Van den Steen1, D Berlato, G Polton
1Centre for Small Animal Studies, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk.
Canine rectal lymphoma, often a B-cell lymphoma, shows a favorable prognosis. Dogs treated with chemotherapy, including COP or CHOP protocols, experienced significantly longer survival times.
Area of Science:
- Veterinary Oncology
- Canine Cancer Research
- Surgical Pathology
Background:
- Rectal lymphoma is a rare condition in dogs.
- Understanding its clinical behavior and immunophenotype is crucial for effective treatment.
Purpose of the Study:
- To retrospectively evaluate the clinical behavior of canine rectal lymphoma.
- To determine the immunophenotype of rectal lymphoma in dogs.
Main Methods:
- Retrospective review of 11 dogs diagnosed with rectal lymphoma.
- Immunohistochemistry using CD3 and CD79a antibodies was performed.
- Analysis of treatment protocols and survival times.
Main Results:
- All examined cases (10/11) showed immunophenotype consistent with B-cell lymphoma.
- Dogs receiving chemotherapy survived significantly longer (mean 1697 days) than those without (70 days).
- Treatment varied, including surgery, chemotherapy (COP or CHOP-based), or symptomatic care.
Conclusions:
- Canine rectal lymphoma is associated with a favorable prognosis.
- Immunohistochemistry consistently identified these lesions as B-cell lymphoma.
- Chemotherapy appears to be a key factor in improving survival outcomes.
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