Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Somatic Spinal Reflexes

Somatic Spinal Reflexes

Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes.

Nature communications·2025

Same author

Tendon mechanobiology in small-animal experiments during post-transection healing.

European cells & materials·2021

Same author

Different composition of leucocytes in cortical and cancellous bone healing in a mouse model.

Bone & joint research·2019

Same author

Undisturbed local bone formation capacity in patients with atypical femoral fractures: a case series.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2017

Same author

Local bisphosphonate reduces migration and formation of radiolucent lines adjacent to cemented acetabular components.

The bone & joint journal·2017

Same author

Randomised trial of bisphosphonate-coated dental implants: Radiographic follow-up after five years of loading.

International journal of oral and maxillofacial surgery·2016

Search research articles

Related Experiment Video

Updated: May 19, 2026

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Trigger finger, tendinosis, and intratendinous gene expression.

A-C Lundin¹, P Aspenberg, P Eliasson

¹Department of Hand Surgery, Plastic Surgery and Burns, Linkoping University Hospital, Linkoping, Sweden.

Scandinavian Journal of Medicine & Science in Sports

|August 14, 2012

Summary

Trigger finger may be a form of tendinosis, similar to Achilles tendinosis. Gene expression in trigger finger tendons shows significant changes, supporting this tendinosis hypothesis.

Keywords:

qPCR quantitative real-time PCR stenosing tendovaginitis tendinopathy tendinosis tendovaginitis stenosans

More Related Videos

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Published on: December 8, 2023

Related Experiment Videos

Last Updated: May 19, 2026

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Published on: December 8, 2023

Area of Science:

Orthopedics
Molecular Biology
Rheumatology

Background:

Trigger finger pathogenesis traditionally linked to annular ligament changes.
Recent findings suggest tendon pathology in trigger finger, akin to Achilles tendinosis.

Purpose of the Study:

To investigate gene expression differences in trigger finger tendons compared to healthy tendons.
To determine if trigger finger exhibits a gene expression pattern similar to Achilles tendinosis.

Main Methods:

Quantitative real-time polymerase chain reaction (PCR) on finger flexor tendon biopsies.
Analysis of 10 specific genes previously associated with tendinosis in 13 trigger fingers and 13 controls.

Main Results:

Significant upregulation of collagen types 1a1 and 3a1, aggrecan, and biglycan in trigger finger tendons.
Significant downregulation of matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinase-3 (TIMP-3).
Observed gene expression changes mirror those found in Achilles tendinosis.

Conclusions:

Gene expression patterns support the hypothesis that trigger finger is a tendinosis.
Findings suggest trigger finger may serve as a model for tendinosis research, potentially impacting surgical treatments.