Related Experiment Video

Updated: May 19, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Receptor tyrosine kinase inhibitors: molecularly targeted drugs for veterinary cancer therapy

S Bavcar1, D J Argyle

  • 1Royal (Dick) School of Veterinary Studies and Roslin Institute, The University of Ediburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Veterinary and Comparative Oncology
|August 14, 2012
PubMed

Insights

Tyrosine kinases (TKs) are crucial cell signaling proteins involved in normal cellular functions. Aberrant TK activity drives cancer development, making Receptor Tyrosine Kinases (RTKs) vital targets for novel cancer therapies.

Area of Science:

  • Cellular Biology
  • Oncology
  • Molecular Signaling

Background:

  • Tyrosine kinases (TKs) are essential proteins regulating cellular signaling pathways.
  • TKs are implicated in normal cellular processes and are crucial in cancer development, progression, and metastasis.
  • Receptor Tyrosine Kinases (RTKs), comprising 70% of TKs, are significant in oncogenesis.

Purpose of the Study:

  • To provide an introductory overview of TKs and their role in cancer.
  • To highlight RTKs as key targets for cancer therapy.
  • To serve as a prelude to a special edition on Veterinary and Comparative Oncology.

Main Methods:

  • Literature review and synopsis of TK functions.
  • Focus on the role of RTKs in cellular signaling and cancer.
  • Discussion of TKs as therapeutic targets in oncology.

Main Results:

  • TKs are central to intracellular and cell surface signaling.
  • Dysregulation of TKs contributes significantly to various cancers.
  • RTKs represent a major class of targets for anti-cancer drug development.

Conclusions:

  • TKs are fundamental to cell signaling and cancer biology.
  • Targeting RTKs offers a promising strategy for cancer treatment.
  • Understanding TKs is critical for advancing targeted cancer therapies.

More Related Videos

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...