Related Experiment Video

Updated: May 19, 2026

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Risk factors for community-acquired urinary tract infection caused by ESBL-producing bacteria in children

Ozgur Kizilca1, Rengin Siraneci, Alev Yilmaz

  • 1Department of Pediatrics, Bakirkoy Maternity and Children's Hospital, Istanbul, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 14, 2012
PubMed

Insights

Infants under one year old and recurrent urinary tract infections (UTIs) are key risk factors for infections caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria in children. Preventing UTIs, especially in infants, is crucial for managing antimicrobial resistance.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Urinary tract infections (UTIs) in children can be caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria, leading to antimicrobial resistance.
  • Identifying risk factors for these infections is crucial for effective management and treatment strategies.

Purpose of the Study:

  • To investigate the risk factors associated with pediatric urinary tract infections caused by ESBL-producing bacteria.
  • To understand the antibiotic resistance patterns of ESBL-producing versus non-ESBL-producing bacteria in pediatric UTIs.

Main Methods:

  • A retrospective study of 344 pediatric UTI patients from January 2008 to December 2009.
  • Categorization of patients based on causative microorganisms: ESBL-producing bacteria (148 patients) and non-ESBL-producing bacteria (196 patients).
  • Analysis of demographic data, clinical history, and antibiotic resistance profiles.

Main Results:

  • Escherichia coli and Klebsiella species were the most frequent causative agents, with significant proportions of ESBL production.
  • ESBL-producing bacteria exhibited higher resistance rates to trimethoprim/sulfamethoxazole, quinolones, and aminoglycosides compared to non-ESBL-producing bacteria.
  • Significant risk factors for ESBL-producing bacteria included age under 1 year, high UTI recurrence rate, prolonged prophylactic antibiotic use, cephalosporin prophylaxis, recent hospitalization, and clean intermittent catheterization.

Conclusions:

  • Age under 1 year and high UTI recurrence rate were identified as independent risk factors for ESBL-producing bacterial infections in children.
  • Preventing UTIs, particularly in the first year of life, and avoiding prophylactic cephalosporins are recommended to mitigate the risk of ESBL-producing bacterial infections.
Abstract

More Related Videos

Establishment and Characterization of UTI and CAUTI in a Mouse Model08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis07:34

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Published on: April 16, 2019

Related Concept Videos

Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...