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Related Experiment Video

Updated: May 19, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

Chapter 12: Yale lung cancer model.

Theodore R Holford1, Keita Ebisu, Lisa McKay

  • 1Yale School of Public Health, 60 College St., New Haven, CT 06520, USA. theodore.holford@yale.edu

Risk Analysis : an Official Publication of the Society for Risk Analysis
|August 14, 2012
PubMed
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This summary is machine-generated.

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Trends for the Impact of Cigarette Smoking on Mortality in US States.

medRxiv : the preprint server for health sciences·2026

This study used an age-period-cohort model with smoking carcinogenesis models to analyze lung cancer deaths. Tobacco control efforts prevented 35.2% of male and 26.5% of female lung cancer deaths.

Area of Science:

  • Epidemiology
  • Biostatistics
  • Cancer Research

Background:

  • Age-period-cohort models effectively describe lung cancer incidence and mortality trends.
  • Integrating carcinogenesis models for smoking enhances temporal trend analysis.

Purpose of the Study:

  • To extend the age-period-cohort model to incorporate smoking carcinogenesis models.
  • To temporally calibrate population data models and assess limitations of carcinogenesis models.
  • To estimate the impact of tobacco control on lung cancer mortality.

Main Methods:

  • Utilized an age-period-cohort modeling framework.
  • Embedded the two-stage clonal expansion model for smoking carcinogenesis.
  • Compared observed lung cancer deaths against hypothetical scenarios of no control versus ideal control (1965).

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Last Updated: May 19, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

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08:31

Acellular and Cellular Lung Model to Study Tumor Metastasis

Published on: August 19, 2018

A Minimally Invasive Method for Generating a Syngeneic Orthotopic Mouse Model of Lung Cancer
07:46

A Minimally Invasive Method for Generating a Syngeneic Orthotopic Mouse Model of Lung Cancer

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Main Results:

  • The integrated model successfully calibrated population data and identified temporal limitations.
  • Estimated that 35.2% of potential lung cancer deaths were avoided in males due to tobacco control.
  • Estimated that 26.5% of potential lung cancer deaths were avoided in females due to tobacco control.

Conclusions:

  • The age-period-cohort and carcinogenesis model integration provides a robust framework for analyzing lung cancer trends.
  • Significant reductions in lung cancer mortality have been achieved through tobacco control measures since 1965.
  • The model highlights the substantial impact of public health interventions on cancer outcomes.