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Related Experiment Video

Updated: May 19, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

[Acute leukemia frequency observed in a reference hospital].

Wendy Marlene González-Salas¹, Irma Olarte-Carrillo, Mario Gutiérrez-Romero

¹Departamento de Hematología, Hospital General de México, Secretaría de Salud, Distrito Federal, México. wendy_gon@hotmail.com

Revista Medica Del Instituto Mexicano Del Seguro Social

|August 14, 2012

Summary

Acute lymphoid leukemia (ALL) became more frequent than acute myeloid leukemia (AML) in a Mexico City hospital between 1990-1992 and 2008-2009. Increased use of advanced diagnostics likely contributed to this shift.

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Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

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Last Updated: May 19, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

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Published on: March 5, 2018

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

Area of Science:

Hematology
Oncology
Epidemiology

Background:

Acute leukemia is a significant cause of morbidity and mortality.
Understanding trends in acute leukemia subtypes is crucial for public health.
Previous studies show varying frequencies of acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML).

Purpose of the Study:

To compare the frequency of acute leukemia subtypes in two distinct periods (1990-1992 and 2008-2009) at a reference hospital in Mexico City.
To identify changes in the incidence of ALL and AML over time.

Main Methods:

An observational study was conducted.
Data from 250 cases diagnosed with acute leukemia based on morphology were analyzed.
Case frequencies were compared between the two study periods.

Main Results:

Acute lymphoid leukemia (ALL) was the most frequent subtype, accounting for 62% of cases, compared to 38% for acute myeloid leukemia (AML).
In the 2008-2009 period, there was a significant increase in admissions for acute leukemia.
Acute promyelocytic leukemia also showed a statistically significant increase (p = 0.001).

Conclusions:

Acute leukemia remains a primary cause of hospital admission, mortality, and morbidity.
The observed increase in ALL frequency in the later period aligns with findings from this study, differing slightly from some literature.
The rise in specific leukemia diagnoses is attributed to advancements in diagnostic tools, including flow cytometry and molecular biology.