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Updated: May 19, 2026

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
Published on: September 16, 2020
Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer
Pablo M Arce1, Ruth Goldschmidt, Omar M Khdour
1Center for BioEnergetics, Biodesign Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, United States.
Abstract:
Selected pyridinol analogues of the experimental neuroprotective drug idebenone have been synthesized and evaluated as antioxidants capable of preserving mitochondrial function. The compounds, having a different redox core but the same side chain as idebenone, exhibited a range of potencies, reflecting differences in their structures. The results obtained provide guidance in the design of such analogues with improved properties. Analogues were identified that have significantly improved antioxidant activity compared with idebenone in cultured lymphocytes, and which exhibit lesser inhibition of the electron transport chain.
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