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Published on: March 23, 2022
[Clinical analysis of drug-induced Pseudo-Bartter's syndrome: a report of five cases]
Feng-Ao Li1, Hong-Yan Wei, Shan Lin
1Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Objective:
To summarize the clinical characteristics and outcomes of Pseudo-Bartter's syndrome and explore its pathogenesis.
Methods:
The clinical data of 5 cases of Pseudo-Bartter's syndrome at our ward from May 2008 to December 2010 was analyzed retrospectively.
Results:
All patients were female. Long-term regimen of purgative or diuretics was prescribed. The clinical features included normotension, hypokalemic alkalosis and activation of renin-angiotensin-aldosterone. The pathological results of 3 cases of kidney biopsy showed the hyperplasia of juxtaglomerular apparatus, thickness of arteriole, infiltration of lymphocytes and monocytes and degeneration of renal tubule. Upon a definitive diagnosis, purgative or diuretics was discontinued and supplement therapy of potassium chloride initiated. The results of laboratory tests reverted to normal ranges within 4 weeks.
Conclusion:
Purgative or diuretics should be prescribed appropriately to avoid the occurrence of Pseudo-Bartter's syndrome.
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