Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 19, 2026

Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease
07:25

Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease

Published on: November 24, 2014

[MicroRNAs expression in normal and dissected aortic tissue].

Zi-yang Hu1, Jian-fang Luo, Shi-long Zhong

  • 1Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|August 14, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SPP1 promotes fatty acid synthesis in macrophages to drive silicosis.

Cellular signalling·2026
Same author

LncRNA H19 drives atherosclerosis progression via the miR-let-7a/ITGB3 axis.

Frontiers in physiology·2026
Same author

Pathology illustrates pathogenesis of indium lung diseases in rats induced by indium-tin oxide nanoparticles.

Free radical biology & medicine·2026
Same author

Photoinduced Cyclization of 2-Alkynylanilines to Access 3-Bromoindole Scaffolds.

The Journal of organic chemistry·2026
Same author

Sulforaphane attenuates oxidative stress and vascular remodeling in indium lung disease rats via mediating the NF-κB and Nrf2 pathways.

Toxicology and applied pharmacology·2026
Same author

Multidimensional analysis of pulmonary tuberculosis epidemiological characteristics in Jining City from 2010 to 2024: an integrated study based on spatial clustering, trend regression, and age-period-cohort modeling.

Frontiers in public health·2026
Same journal

[Multidisciplinary expert consensus on the prevention and treatment of gastrointestinal mucosal injury induced by antiplatelet drugs].

Zhonghua xin xue guan bing za zhi·2026
Same journal

[<i>Practical Cardiology</i>: the driving force behind my academic journey].

Zhonghua xin xue guan bing za zhi·2026
Same journal

[The role and mechanism of transient receptor potential M2 channel-mediated calcium homeostasis imbalance in the development of diabetic cardiomyopathy].

Zhonghua xin xue guan bing za zhi·2026
Same journal

[Advances of 18 kDa translocator protein (TSPO) in cardiovascular diseases: molecular imaging diagnosis and targeted therapy perspectives].

Zhonghua xin xue guan bing za zhi·2026
Same journal

[New progress in diagnosis and treatment of hypertrophic cardiomyopathy with left ventricular apical aneurysm].

Zhonghua xin xue guan bing za zhi·2026
Same journal

[Research progress of wearable devices in cardiovascular disease management].

Zhonghua xin xue guan bing za zhi·2026
See all related articles

Altered microRNAs (miRNAs) expression is linked to aortic dissection. Specifically, hsa-miR-146b-5p may serve as a diagnostic biomarker for this condition.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Context:

  • Aortic dissection (Debakey Type A) is a life-threatening condition.
  • Understanding the molecular mechanisms underlying aortic dissection is crucial for diagnosis and treatment.
  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and are implicated in various diseases.

Purpose:

  • To investigate differential miRNA expression in aortic dissection (AD) versus normal aorta (NA) tissue.
  • To identify specific miRNAs that are altered in AD pathogenesis.
  • To explore the potential of miRNAs as diagnostic biomarkers for AD.

Summary:

  • miRNA expression profiling was performed on aortic tissues from patients with AD and NA.
  • Significant upregulation of hsa-miR-146b-5p_st, hsa-miR-19a_st, and hsa-miR-505_st was observed in AD.

More Related Videos

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

Related Experiment Videos

Last Updated: May 19, 2026

Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease
07:25

Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease

Published on: November 24, 2014

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

  • Downregulation of hsa-miR-1268_st and hsa-miR-939_st was noted in AD, with hsa-miR-146b-5p_st expression verified by RT-PCR.

    • Impact:

    • Altered miRNA expression plays a role in the pathogenesis of aortic dissection.
    • hsa-miR-146b-5p_st shows potential as a novel diagnostic biomarker for aortic dissection.
    • This research contributes to understanding the molecular basis of aortic dissection and may lead to improved diagnostic strategies.