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Taok2 controls behavioral response to ethanol in mice.

D Kapfhamer¹, S Taylor, M E Zou

¹The Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA. dkapfhamer@gallo.ucsf.edu

Genes, Brain, and Behavior

|August 14, 2012

Summary

Researchers identified a gene, Taok2, that influences how mice respond to ethanol. This finding suggests Taok2 may play a role in human alcohol use disorders, offering new insights into ethanol

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Area of Science:

Neuroscience
Genetics
Pharmacology

Background:

Ethanol's molecular targets and behavioral mechanisms are not fully understood.
Identifying genes that regulate ethanol's effects is crucial for understanding alcohol's biological action.

Purpose of the Study:

To identify novel genes influencing behavioral responses to ethanol.
To investigate the role of the dtao gene homolog, Taok2, in ethanol-dependent behaviors in mice.

Main Methods:

Identified a mutation in Drosophila dtao conferring ethanol resistance.
Performed conditional ablation of the mouse Taok2 gene specifically in the nervous system.

Main Results:

Conditional ablation of Taok2 in mice led to strain-specific alterations in ethanol-dependent behaviors.

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Observed functional conservation between Drosophila dtao and mouse Taok2 in mediating ethanol's effects.

Conclusions:

Taok2 is functionally conserved with dtao in regulating ethanol's biological action.
Taok2 is a potential candidate gene for human ethanol use disorders.