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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Related Experiment Video

Updated: May 19, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

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Published on: August 14, 2019

Longitudinal volumetric changes following traumatic brain injury: a tensor-based morphometry study.

Kimberly D M Farbota1, Aparna Sodhi, Barbara B Bendlin

  • 1Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53792, USA. kim.farbota@gmail.com

Journal of the International Neuropsychological Society : JINS
|August 14, 2012
PubMed
Summary
This summary is machine-generated.

Traumatic brain injury (TBI) causes prolonged brain atrophy, particularly in white matter, for years post-injury. This ongoing brain volume loss correlates with cognitive changes, suggesting continued brain plasticity and potential for subtle recovery.

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Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Traumatic brain injury (TBI) leads to long-term brain degeneration alongside cognitive recovery.
  • The precise timing and patterns of brain atrophy and its relation to cognitive changes after TBI are not fully understood.

Purpose of the Study:

  • To investigate the spatiotemporal pattern of brain volume loss and its relationship with cognitive changes over four years in traumatic brain injury patients.

Main Methods:

  • Utilized tensor-based morphometry and neuropsychological testing in 17 TBI patients and 13 controls.
  • Acquired brain scans at 2 months, 1 year, and 4 years post-injury.
  • Employed high-dimensional warping to generate brain change maps for detailed volumetric analysis.

Main Results:

  • TBI patients showed significant volume loss in cortical and white matter regions within the first year.
  • Continued extensive white matter volume loss was observed between 1 and 4 years post-injury.
  • Cognitive performance correlated with subsequent volume loss in relevant brain regions.

Conclusions:

  • The injured brain exhibits prolonged malleability, with significant white matter atrophy extending beyond the first year.
  • Observed correlations suggest that ongoing brain volume changes are linked to subtle cognitive improvements after TBI.