Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 19, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
08:01

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

[Blastic plasmacytoid dendritic cell neoplasm: a clinicopathologic study].

Wei Sang1, Chao-fu Wang, Yu-fan Cheng

  • 1Department of Pathology, Xinjiang Medical University First Hospital, Urumqi 830054, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|August 14, 2012
PubMed
Summary

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. This study details its diverse clinicopathologic and immunophenotypic features, aiding differential diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

All-Solid-State Confinement Synthesis of PtFe Alloy Anchored on N-Doped Carbon for Acidic Oxygen Reduction.

ACS applied materials & interfaces·2026
Same author

Deformation behaviour of over-consolidated soil in a deep confined aquifer under multi-stage pore pressure changes in Shanghai, China.

Scientific reports·2026
Same author

Transcriptome reveals probiotics mitigating MCLR-induced reproductive toxicity in male zebrafish: Regulation of reproductive endocrine, oxidative stress, and inflammatory response.

Journal of environmental sciences (China)·2026
Same author

Case Report: Neuromyelitis optica spectrum disorder associated with gastric cardia and pancreatic cancers: clinical features and oncological implications.

Frontiers in oncology·2026
Same author

Anti-BCMA/GPRC5D CAR T in relapsed or refractory multiple myeloma patients with extraosseous extramedullary disease.

Blood·2026
Same author

3D-Printing Starfish-Inspired Gas-Evolving Electrode Scaffolds Enable Ampere-Level Alkaline Water Electrolysis.

Advanced materials (Deerfield Beach, Fla.)·2026

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy.
  • It is characterized by neoplastic proliferation of precursors of plasmacytoid dendritic cells.
  • Understanding its clinicopathologic and immunophenotypic spectrum is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To investigate the clinicopathologic features of BPDCN.
  • To explore the differential diagnosis of BPDCN.
  • To analyze the heterogeneous immunophenotypic profiles observed in BPDCN cases.

Main Methods:

  • Analysis of clinical, morphological, and immunophenotypic data from 3 BPDCN cases.
  • Comprehensive review of existing literature on BPDCN.

More Related Videos

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
12:58

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

Related Experiment Videos

Last Updated: May 19, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
08:01

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
12:58

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

  • Detailed examination of specific immunophenotypic markers (e.g., CD56, CD4, CD123, TdT, CD43, CD68).

    • Main Results:

    • The 3 cases exhibited pathological changes consistent with BPDCN.
    • Observed immunophenotypes included CD56(+) CD4(-) CD123(+) TdT(+) CD43(+) CD68(+), CD56(+) CD4(+) CD123(-) TdT(+) CD43(+) CD68(-), and CD56(+) CD4(+) CD123(-/+) TdT(-) CD43(+) CD68(+).
    • Bone marrow involvement occurred in one case 5 years post-diagnosis, with variable patient outcomes.

    Conclusions:

    • BPDCN represents a heterogeneous group of lymphoproliferative disorders.
    • Significant variations exist in clinical presentation, morphology, and immunophenotypic characteristics.
    • Accurate diagnosis requires careful consideration of these diverse features.