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Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...

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Related Experiment Video

Updated: May 19, 2026

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
12:37

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

Published on: October 7, 2015

In situ chondrocyte viscoelasticity.

Sang-Kuy Han1, Ryan Madden, Ziad Abusara

  • 1Human Performance Laboratory, University of Calgary, Canada.

Journal of Biomechanics
|August 14, 2012
PubMed
Summary

Cartilage

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Biomechanics

Background:

  • Theoretical models suggest cartilage's viscoelasticity protects chondrocytes from deformation during cyclic loading.
  • Previous experimental studies have not investigated the in situ viscoelastic response of chondrocytes.
  • Studies on isolated chondrocytes in gels may not reflect in vivo behavior.

Purpose of the Study:

  • To investigate the in situ viscoelastic response of chondrocytes within native cartilage.
  • To assess chondrocyte behavior under static and cyclic mechanical compression.
  • To utilize a novel in situ experimental approach.

Main Methods:

  • Developed and employed a novel in situ experimental technique.
  • Applied static and cyclic mechanical compression to cartilage explants.

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A Microfluidic Platform for Stimulating Chondrocytes with Dynamic Compression

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Last Updated: May 19, 2026

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
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Mechanical Stimulation of Chondrocyte-agarose Hydrogels
12:45

Mechanical Stimulation of Chondrocyte-agarose Hydrogels

Published on: October 27, 2012

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A Microfluidic Platform for Stimulating Chondrocytes with Dynamic Compression

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  • Observed and quantified chondrocyte and matrix recovery post-compression.

    • Main Results:

    • Cartilage matrix and chondrocytes exhibited significant in situ viscoelastic recovery.
    • Recovery times were consistent with previous in vivo studies of chondrocyte mechanics.
    • Demonstrated that cartilage viscoelasticity minimizes chondrocyte deformation under dynamic loading.

    Conclusions:

    • The viscoelastic properties of cartilage effectively minimize chondrocyte deformations during dynamic loading.
    • This protective mechanism allows chondrocytes to maintain mechanical and metabolic homeostasis in joints during locomotion.
    • In situ investigation is crucial for understanding chondrocyte mechanobiology in native tissue.