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A preliminary study on correlation between adiponectin genotype polymorphisms and obstructive sleep apnea hypopnea
Juan Cao1, Shi-Cheng Su, Han-Peng Huang
1Department of Geriatric Medicine, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214194, China.
This study found no direct link between adiponectin gene variations and obstructive sleep apnea hypopnea syndrome (OSAHS). However, specific adiponectin genotypes in OSAHS patients may indicate increased health risks.
Area of Science:
- Genetics
- Sleep Medicine
- Metabolic Disorders
Background:
- Obstructive sleep apnea hypopnea syndrome (OSAHS) has a significant genetic component and is linked to low adiponectin levels.
- Investigating adiponectin gene single nucleotide polymorphisms (SNPs) may reveal associations with OSAHS.
Purpose of the Study:
- To explore the correlation between adiponectin gene SNPs at positions 45 and 276 and OSAHS in a Chinese Han population.
- To analyze the association of adiponectin genotype polymorphisms with OSAHS and related clinical parameters.
Main Methods:
- Employed the TaqMan polymerase chain reaction (PCR) method to genotype adiponectin SNPs.
- Studied 103 OSAHS patients and 67 normal controls from Nanjing district.
- Performed statistical analysis to assess genotype-phenotype and genotype-OSAHS associations.
Main Results:
- No direct association was found between OSAHS and adiponectin genotype SNPs at positions 45 and 276 (P > 0.05).
- OSAHS patients with the adiponectin G/G genotype at position 276 exhibited longer neck circumference, prolonged apnea duration, and elevated cholesterol and LDL levels compared to G/T + T/T genotypes (P < 0.05).
Conclusions:
- No direct association between OSAHS and adiponectin genotype distribution at positions 45 and 276 was observed in the studied population.
- The adiponectin G/G genotype at position 276 may be associated with a higher potential risk for OSAHS development in affected individuals.
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