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Updated: May 19, 2026
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
A patient with steroid responsive encephalopathy associated with autoimmune thyroiditis
Benjamin K-T Tsang1, Nicholas Crump, Andrew J Hughes
1Department of Neurology, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia. bktsang@optusnet.com.au
Summary
Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SEAT) can cause cognitive decline and gait issues. Prompt diagnosis and steroid treatment led to significant patient recovery.
Area of Science:
- Neurology
- Immunology
- Endocrinology
Background:
- Autoimmune thyroiditis is an endocrine disorder.
- Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SEAT) is a rare neurological condition.
Observation:
- A 58-year-old female presented with cognitive decline and gait instability.
- Clinical findings included myoclonus, brisk reflexes, and impaired cognition.
- Brain MRI revealed white matter abnormalities, and elevated thyroid antibodies were detected.
Findings:
- Cerebrospinal fluid showed elevated protein.
- Electroencephalography demonstrated bitemporal slowing.
- Diagnosis of SEAT was confirmed by clinical and laboratory findings.
Implications:
- Early diagnosis and treatment of SEAT are crucial for patient recovery.
- This case highlights the importance of considering autoimmune conditions in neurological presentations.
- Steroid therapy can effectively manage SEAT, improving neurological function.
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