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Related Experiment Video

Updated: May 19, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Interleukin-1 beta gene polymorphisms and preterm birth.

Maximilian Schmid¹, Peter Haslinger, Susanne Stary

¹Department of Obstetrics and Gynecology, Medical University of Vienna General Hospital, Vienna, Austria. maximilian.schmid@meduniwien.ac.at

European Journal of Obstetrics, Gynecology, and Reproductive Biology

|August 14, 2012

Summary

The Interleukin-1 beta (IL1B) +3953C>T gene variation is linked to a reduced risk of preterm birth in Caucasian women. This genetic factor may influence pregnancy inflammatory responses, impacting birth timing.

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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

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Last Updated: May 19, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

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Published on: June 24, 2020

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Area of Science:

Genetics
Obstetrics
Immunology

Background:

Preterm birth is a significant global health concern with complex etiologies.
The Interleukin-1 beta (IL1B) gene plays a role in inflammatory processes, which are implicated in pregnancy.

Purpose of the Study:

To examine the association between specific genetic polymorphisms in the IL1B gene and the occurrence of preterm birth.
Investigate the potential role of IL1B variants in modulating preterm birth risk.

Main Methods:

A case-control study was conducted with 100 women experiencing preterm birth and 100 healthy controls.
Genotyping was performed for two common IL1B polymorphisms: +3953C>T (rs1143634) and -511C>T (rs16944).
Allelic distributions were compared between cases and controls.

Main Results:

A statistically significant association was observed between the IL1B +3953C>T polymorphism and preterm birth (p=0.049, OR 0.6).
The IL1B -511C>T polymorphism did not show a significant association with preterm birth (p=0.471, OR 1.3).

Conclusions:

The IL1B +3953C>T polymorphism appears to be associated with a reduced risk of preterm birth in Caucasian women.
This genetic variation may influence pregnancy outcomes by modulating the maternal inflammatory response.