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Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...

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Related Experiment Video

Updated: May 19, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

Primary disseminated extrapulmonary multidrug resistant tuberculosis.

S K Das1, A Das, A Gangopadhyay

  • 1Department of Respiratory Medicine, Medical College, Kolkata, West Bengal, India.

Indian Journal of Medical Microbiology
|August 14, 2012
PubMed
Summary
This summary is machine-generated.

A rare case of disseminated tuberculosis with primary multidrug resistance in an immunocompetent adult is presented. This involved extrapulmonary sites and required specialized treatment for resistant Mycobacterium tuberculosis.

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Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
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Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

Related Experiment Videos

Last Updated: May 19, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
07:35

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pulmonology

Background:

  • Disseminated tuberculosis is common in India, affecting both HIV/AIDS and non-HIV patients.
  • Primary multidrug resistance in disseminated tuberculosis, particularly in immunocompetent adults with only extrapulmonary involvement, is uncommon.

Observation:

  • A 19-year-old immunocompetent male presented with disseminated tuberculosis affecting the pleura, pericardium, peritoneum, and intraabdominal lymph nodes.
  • Initial treatment with WHO Category I antitubercular drugs for 5 months showed no improvement.

Findings:

  • Mycobacterium tuberculosis isolated from pleural biopsy demonstrated resistance to isoniazid and rifampicin, indicating primary multidrug resistance.
  • The patient was subsequently treated with a multidrug-resistant tuberculosis regimen.

Implications:

  • This case highlights the importance of considering multidrug-resistant tuberculosis even in immunocompetent individuals with extrapulmonary disseminated disease.
  • Successful treatment of multidrug-resistant tuberculosis in such cases necessitates tailored, extended chemotherapy regimens.