New therapies against HCV: expected risks and challenges associated with their use in the liver transplant setting

Here, we present a protocol to establish a long-term liver cold storage and transplantation model in Daurian ground squirrel (DGS), which has been technically challenging in standard rodent models.

Portal vein thrombosis (PVT) is a frequent complication in patients with portal hypertension resulting from end-stage liver disease. In certain instances, PVT may be a contraindication for liver transplantation. We have developed a novel approach for managing PVT cases involving complete occlusion of the main trunk of the portal...

John is evaluating a job offer from a company where his income will be uncertain. If the company performs well, John will earn an annual income of  $81,000; otherwise, he will earn $49,000. It is assumed that either outcome has an equal chance, assigning a probability of 0.5 to each. This results in an expected income of $65,000. His decision-making is affected by the diminishing marginal utility of income. John evaluates his options based on their utility. Expected utility accounts...

Consider a hypothetical example where John is evaluating a job offer from a company. If the company performs well, John will earn an annual income of  $81,000; if it performs poorly, he will earn $49,000. Each outcome is equally likely, with a probability of 0.5. These two outcomes are mutually exclusive, meaning only one can occur and their probabilities sum to 1. The amounts of $81,000 and $49,000 represent the payoffs associated with each outcome.John's expected income is the average...

This protocol outlines the methodology of establishing a porcine model utilizing variable temperature-controlled Machine Perfusion (MP) for the preservation of the donor liver, followed by orthotopic liver transplantation (OLTx). It aims to promote the success rate of OLTx using donor donation after circulatory death (DCD) liver and establish a stable...

In this protocol, we discuss the implementation of a model of successful orthotopic liver transplantation (OLT) in mice. Additionally, adjuvants to further analyze allograft patency after successful OLT in a mouse are discussed as well, specifically utilizing microcomputed tomography (microCT) scans.