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Use of infliximab in a patient with rheumatoid arthritis and chronic hepatitis B
Eloisa Doubrawa1, Renê Augusto de Mattos Ricca, Tiago Osternack Malucelli
1Hospital de Clínicas, Universidade Federal do Paraná, Rua Nilo Cairo 36/105, Curitiba, PR, Brazil. eloisadoubrawa@yahoo.com.br
Abstract:
Anti-TNF-α agents have emerged as a potent treatment for patients with rheumatoid arthritis unresponsive to conventional disease-modifying antirheumatic drugs. Increased susceptibility to infections induced by these drugs is the main complication of their use. Reactivation of hepatitis B virus (HBV) is one of the most worrisome side effects in patients with HBV infection receiving anti-TNF-α. We report the case of a 56-year-old male patient with stable hepatitis B and good response to the antiviral combination of lamivudine and tenofovir when infliximab was started. The patient went into remission. During the 30-month treatment with the biologic, his liver function remained stable, with no HBV reactivation.
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