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Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells
12:16

Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells

Published on: December 17, 2015

[Virulent properties of Porphyromonas gingivalis clinical strains]

Yun-peng Li1, Da-li Liu, Rong Shu

  • 1Department of Periodontology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, China. inzaghi343882@gmail.com

Shanghai Kou Qiang Yi Xue = Shanghai Journal of Stomatology
|August 14, 2012
PubMed
Abstract

Insights

Virulence varies among clinical strains of Porphyromonas gingivalis. Some strains caused localized abscesses, while others spread, indicating invasive properties in the mouse abscess model (MAM).

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Periodontology

Background:

  • Porphyromonas gingivalis is a key pathogen in periodontitis.
  • Understanding the virulence of clinical isolates is crucial for disease management.

Purpose of the Study:

  • To investigate and compare the virulent properties of P. gingivalis clinical strains.
  • To assess the invasiveness and systemic potential of different isolates.

Main Methods:

  • Utilized a mouse abscess model (MAM) with BALB/C mice.
  • Subcutaneously inoculated six P. gingivalis clinical strains (L2-L5, L11-L12) and type strains (W83, ATCC 33277).
  • Observed clinical signs and analyzed lesion spread and systemic reactions; statistical analysis performed using SPSS 11.5.

Main Results:

  • Strains L3, ATCC 33277, and W83 were noninvasive, causing localized abscesses.
  • Strains L2, L5, L11, and L12 were classified as invasive, with lesions spreading to distant organs and causing systemic reactions.
  • Significant differences in virulence were observed among the tested P. gingivalis clinical strains.

Conclusions:

  • P. gingivalis clinical strains exhibit diverse virulent properties.
  • Findings suggest variability in pathogenic potential among isolates from Chinese patients, similar to type strains in the mouse model.

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