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Synthesizing Amino Acids Modified with Reactive Carbonyls in Silico to Assess Structural Effects Using Molecular Dynamics Simulations
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Improvement of proteolytic stability through in silico engineering

Lucy Rutten1, Hans de Haard, Theo Verrips

  • 1Biomolecular Imaging, Department of Biology, Utrecht University, Utrecht, The Netherlands. l.rutten@uu.nl

Methods in Molecular Biology (Clifton, N.J.)
|August 14, 2012
PubMed
Summary

This study introduces a method to predict and enhance the proteolytic stability of variable heavy-heavy (VHH) domains. This improves their suitability for therapeutic applications requiring resistance to degradation in the gastrointestinal tract.

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