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Elevated serum resistin in juvenile idiopathic arthritis: relation to categories and disease activity

Tamer A Gheita1, Iman I El-Gazzar, Reem I El Shazly

  • 1Rheumatology Departments, Faculty of Medicine, Cairo University, Cairo, Egypt. gheitamer@hotmail.com

Journal of Clinical Immunology
|August 14, 2012
PubMed

Insights

Serum resistin levels are elevated in children with Juvenile Idiopathic Arthritis (JIA), particularly those with systemic onset. Higher resistin correlates with increased disease activity and functional status, suggesting its potential as a biomarker for JIA.

Area of Science:

  • Rheumatology
  • Pediatrics
  • Immunology

Background:

  • Juvenile Idiopathic Arthritis (JIA) is a chronic childhood disease leading to long-term disability.
  • Understanding biomarkers for JIA is crucial for effective management.

Purpose of the Study:

  • To assess serum resistin levels in JIA patients.
  • To compare resistin levels across JIA categories, clinical features, and disease activity.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum resistin.
  • Sixty-eight JIA patients and 33 controls were included.
  • Disease activity and functional status were assessed using JADAS-27 and CHAQ.

Main Results:

  • Serum resistin was significantly higher in JIA patients than controls (p<0.001).
  • Elevated resistin was observed in systemic-onset JIA, steroid users, and those with positive antinuclear antibodies.
  • Resistin correlated significantly with JADAS-27 and CHAQ scores.

Conclusions:

  • Resistin plays a significant role in JIA pathogenesis.
  • Resistin may serve as a valuable biomarker for JIA disease activity, especially in systemic-onset cases.
Abstract

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