[Study on protein polymorphism of Chinese KM subcolonies]

This paper presents the results of study on 24 protein markers by means of electrophoresis in 4KM subcolonies maintained in Beijing, Shanghai and Changcun, and compares it with that of one NIH colony introduced from U.S.A. in 1982. The results revealed that: (1) There were few genetic variants on allelic constitutions of Chinese KM mouse colonies, and the genetic distance among KM subcolonies is 0.008-0.027 positively related with the time the colony closed; (2) The unique position of S: KM mouse was shown in phylogenetic diagram of 4 KM subcolonies, which agrees with the result from mandible analysis; (3) The allelic constitutions of KM mice differs from NIH mice a Swiss derivative colony at Es-3, Es-10, Glo-1, Gpt-1, Got-2 and Mpi-1 loci and the average genetic distance between KM and NIH colonies is 0.131 + 0.011, which indicates that Chinese KM mice is one of non-Swiss derivative subspecies.