Related Experiment Videos
Inhibition of fatty acid-supported mitochondrial respiration by cyclosporine
C A Lemmi1, R L Miller, J Rajfer
1Department of Anatomy and Cell Biology, UCLA 90024.
Biochemical Medicine and Metabolic Biology
|December 1, 1990
Abstract:
We have shown that, in addition to inhibition of the succinate-supported energy pathway (5), CS inhibition of mitochondrial Complex II activity also limits fatty acid oxidation. These results are consistent with the participation of altered lipid metabolism in CS nephrotoxicity.