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Visible-light Induced Reduction of Graphene Oxide Using Plasmonic Nanoparticle
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Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells

Alexey V Tkach1, Naveena Yanamala, Shyla Stanley

  • 1Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|August 14, 2012
PubMed

Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60 -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.

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