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Cobalt ion-mediated cysteine detection with a hyperbranched conjugated polyelectrolyte as a new sensing platform
Daigeun Kim1, Geunseok Jang, Jongho Kim
1Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon, Korea.
Abstract:
A highly efficient colorimetric and fluorescence turn-off probe for the sensitive and selective detection of the biologically important amino acid, cysteine (Cys), is demonstrated using a newly synthesized water-soluble hyperbranched polymer (HP) containing sulfonic acid groups. The detection mechanism involves two steps: (i) the slight quenching of HP in the presence of Co(2+) in advance; and (ii) the gradual quenching of the HP-Co(2+) complex according to the concentration of Cys due to the absorption screening effect of the formation of the Cys-Co(2+) complex, which prevents HP from absorbing excitation energy.
