Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 19, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Adjuvant bidirectional chemotherapy using an intraperitoneal port.

Paul H Sugarbaker¹, Lana Bijelic

¹Program in Peritoneal Surface Malignancy, Washington Cancer Institute, Washington, DC 20010, USA.

Gastroenterology Research and Practice

|August 14, 2012

Summary

Adjuvant bidirectional chemotherapy (ABC) can be safely administered after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Simplified intraoperative port placement enables ABC completion in patients with complete cytoreduction, reducing treatment failures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Morphology and Pathophysiology of 10 Different Types of Peritoneal Metastases.

Journal of surgical oncology·2026

Same author

Assessment of Outcome in 198 Patients With Mucinous Appendiceal Adenocarcinoma and Peritoneal Metastases Over 25 Years.

Journal of surgical oncology·2026

Same author

Correction: Secondary and Tertiary Cytoreduction for Colorectal Peritoneal Metastasis-Evaluate and Select Carefully, but Do Not Dismiss.

Annals of surgical oncology·2026

Same author

ASO Visual Abstract: MORPHology and Inter-Observer Variation in Peritoneal Disease Assessment Among Expert Peritoneal Malignancy SUrgeonS-The MORPHEUS Study.

Annals of surgical oncology·2026

Same author

Efficacy and safety of intraoperative hyperthermic intraperitoneal chemotherapy for locally advanced colorectal cancer (HIPECT4): final analysis of randomized clinical trial.

BJS open·2026

Same author

Correction: MORPHology and Inter-observer Variation in Peritoneal Disease Assessment Among Expert Peritoneal Malignancy SUrgeonS: The MORPHEUS study.

Annals of surgical oncology·2026

Area of Science:

Oncology
Surgical Oncology
Chemotherapy

Background:

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are established treatments for peritoneal metastases and mesothelioma.
High rates of local-regional treatment failure persist despite CRS and HIPEC, often due to inadequate chemotherapy delivery.
Improved strategies are needed to supplement CRS and HIPEC and enhance treatment efficacy.

Purpose of the Study:

To evaluate the feasibility and safety of intraoperative intraperitoneal port placement for adjuvant bidirectional chemotherapy (ABC).
To assess the impact of cytoreduction completeness on the tolerance and completion of ABC.
To establish a simplified method for delivering supplementary chemotherapy after CRS and HIPEC.

Main Methods:

More Related Videos

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

Related Experiment Videos

Last Updated: May 19, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

A simplified technique for intraoperative intraperitoneal port placement was developed.

Four distinct ABC chemotherapy regimens were used based on primary malignancy site.

Thirty-one patients undergoing CRS and HIPEC with intraoperative port placement were retrospectively analyzed.

Main Results:

Adverse events leading to early ABC discontinuation occurred in 75% of patients with incomplete cytoreduction (8 patients).
No adverse events caused early discontinuation of ABC in patients who achieved complete cytoreduction.
All patients with complete cytoreduction successfully completed at least 5 of 6 scheduled ABC treatments.

Conclusions:

Intraoperative intraperitoneal port placement offers a simplified approach for adjuvant bidirectional chemotherapy.
Adjuvant bidirectional chemotherapy is feasible and well-tolerated following complete cytoreduction.
This strategy may improve outcomes for patients with peritoneal metastases or mesothelioma treated with CRS and HIPEC.