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Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
Published on: October 30, 2016
Extranodal natural killer/T-cell lymphoma: a diagnostic dilemma
H Yanagi1, Y Nakamura, D Takagi
1Department of Otorhinolaryngology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Rhinology
|August 14, 2012
Summary
Diagnosing extranodal natural killer (NK)/T-cell lymphoma is challenging. Key diagnostic delays stem from inflammatory cell infiltration, necrosis, and poor atypia, necessitating larger biopsies and EBER-ISH testing.
Area of Science:
- Oncology
- Pathology
Background:
- Extranodal natural killer (NK)/T-cell lymphoma diagnosis is frequently delayed, negatively impacting patient prognosis.
- Analyzing factors contributing to diagnostic difficulties is crucial for improving patient outcomes.
Observation:
- Retrospective review of 20 NK/T-cell lymphoma cases identified common diagnostic challenges.
- Factors contributing to delayed diagnosis include insufficient specimen size, massive necrosis, abundant inflammatory cells, and poor cellular atypia.
Findings:
- The average diagnostic delay for NK/T-cell lymphoma was 12.8 months.
- Inflammatory cell infiltration was the most common cause of diagnostic delay.
- Massive necrosis and poor atypia were also significant contributors to delayed diagnosis.
Implications:
- In suspected cases, especially with necrotic nasal or pharyngeal lesions, NK/T-cell lymphoma should be considered.
- Obtaining large biopsy specimens and utilizing Epstein-Barr virus encoded small RNA in situ hybridization (EBER-ISH) are recommended for accurate pathological examination.
- Repeat biopsies may be necessary for definitive diagnosis.
