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Published on: January 17, 2017
Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
1Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia, Medellin, Colombia. jrojasca@gmail.com
Die Pharmazie
|August 15, 2012
Abstract:
Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug release than MCCI-based pellets. MCCII-based pellets showed an immediate diphenydramineHCl release profile comparable to that of Benadryl and a faster griseofulvin release than MCCI-based pellets. MCCII offers potential to use as an alternative pelletization aid.
