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Myocardial injury in patients with chronic hepatitis C infection

Shigeo Maruyama1, Masahiko Koda, Nobuyuki Oyake

  • 1Maruyama Medical Clinic, Hamada, Japan.

Journal of Hepatology
|August 15, 2012
PubMed

Insights

Hepatitis C virus (HCV) infection is linked to myocardial injury. Thallium-201 myocardial scintigraphy revealed perfusion defects in 87% of patients, improving with interferon therapy and viral eradication.

Area of Science:

  • Cardiology
  • Hepatology
  • Virology

Background:

  • The direct link between hepatitis C virus (HCV) and myocardial injury remains unclear.
  • This study investigates myocardial conditions in patients with HCV-related chronic hepatitis.

Purpose of the Study:

  • To investigate the association between myocardial conditions and HCV infection.
  • To assess the impact of interferon therapy on myocardial injury in HCV patients.

Main Methods:

  • 217 patients with chronic HCV underwent ECG, echocardiography, serum tests, and thallium-201 myocardial scintigraphy.
  • Myocardial injury assessed by severity score (SS) based on perfusion defects.
  • SS was monitored before and after interferon (IFN) therapy in 200 patients.

Main Results:

  • Abnormal myocardial perfusion defects (SS) found in 87% of chronic hepatitis C patients.
  • Higher pretreatment SS correlated with histology activity index, HCV RNA titer, and indocyanine green disappearance rate.
  • SS improved with sustained virologic response after IFN therapy, worsened with HCV RNA reappearance in relapsers.

Conclusions:

  • Significant myocardial perfusion defects are prevalent in chronic hepatitis C patients.
  • Interferon therapy leading to viral eradication improved myocardial perfusion defects.
Abstract

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