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Published on: September 29, 2011
Phosphate enrichment of dialysate for use in standard and extended haemodialysis
Leonard M Ebah1, Mehvosh Akhtar, Ian Wilde
1Department of Renal Medicine, Manchester Royal Infirmary, Manchester, UK. leonard.ebah@doctors.org.uk
Background/Aims:
Intensive haemodialysis (HD) sometimes causes hypophosphataemia, but phosphate-containing dialysate is not readily available. We examined the effectiveness of extemporaneously producing a phosphate-rich dialysate for use in HD.
Methods:
Incremental volumes of Fleet® were added to acid concentrate and predicted to deliver dialysate phosphate concentrations of 0.19-1.1 mmol/l, following mixture with ultrapure water and base concentrate by the HD machine.
Results:
The achieved concentrations were close to predicted values (p = 0.77) and remained stable throughout an 8-hour 'treatment' time (p = 0.99). The dialysate phosphate concentration had a linear relationship with the Fleet® volume added, defined by the regression equation y = 172.79 x - 1.47 (R(2) = 0.99, r = 0.99, p = 0.003). The dialysate pH, calcium, magnesium and bicarbonate concentrations did not change over the study period (p = 0.28-0.99). Microscopic analysis under polarised light showed no evidence of crystal formation.
Conclusion:
The study validates a simple, reliable and cost-effective protocol for phosphate supplementation in conventional and extended HD.
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