Related Experiment Video
Updated: May 19, 2026
08:38
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Everolimus in pediatric transplantation.
Lars Pape1, Rainer Ganschow, Thurid Ahlenstiel
1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Hannover Medical School, Hannover, Germany. larspape@t-online.de
Current Opinion in Organ Transplantation
|August 15, 2012
Summary
Everolimus offers significant benefits in pediatric organ transplantation, reducing toxicity and improving outcomes. This immunosuppressant shows promise for safer and more effective post-transplant care in children.
Area of Science:
- Immunology
- Pediatric Medicine
- Transplantation Science
Background:
- Solid-organ transplantation in children presents unique challenges regarding immunosuppression.
- Calcineurin inhibitors are standard but associated with significant toxicities.
- Novel immunosuppressive agents are needed to improve long-term outcomes in pediatric transplant recipients.
Purpose of the Study:
- To review current studies and clinical trials on everolimus in pediatric solid-organ transplantation.
- To evaluate the immunosuppressive effects and clinical outcomes of everolimus in children.
- To assess the safety and efficacy profile of everolimus in this population.
Main Methods:
- Systematic review of relevant literature and clinical trials.
- Analysis of studies focusing on immunosuppression in pediatric organ transplant recipients.
- Evaluation of efficacy, safety, and side-effect profiles.
Main Results:
- Everolimus use in pediatric organ transplantation is linked to reduced calcineurin inhibitor toxicity.
- Improved renal function and a low incidence of acute rejection were observed.
- Everolimus demonstrated an acceptable side-effect profile, decreasing viral infections and posttransplant lymphoproliferative disease risk.
Conclusions:
- Everolimus is an effective immunosuppressant for pediatric solid-organ transplantation with notable advantages.
- It offers benefits including reduced toxicity and improved patient outcomes.
- Further prospective, randomized controlled trials are warranted to confirm these findings.
More Related Videos
Related Concept Videos
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...