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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

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Related Experiment Video

Updated: May 19, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

Circulating microRNAs after cardiac arrest.

Pascal Stammet1, Emeline Goretti, Mélanie Vausort

  • 1Department of Anaesthesia and Intensive Care, Centre Hospitalier, Luxembourg, Luxembourg.

Critical Care Medicine
|August 15, 2012
PubMed
Summary
This summary is machine-generated.

Circulating microRNAs, such as miR-122 and miR-21, show potential as biomarkers for predicting neurological outcome and mortality in cardiac arrest survivors. While modest predictors compared to neuron-specific enolase, their prognostic value warrants further investigation in larger patient cohorts.

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Area of Science:

  • Biomarkers
  • Neuroscience
  • Intensive Care Medicine

Background:

  • Predicting clinical outcomes after cardiac arrest is crucial for patient management.
  • Circulating microRNAs are being investigated as biomarkers for acute coronary syndromes.
  • The prognostic role of microRNAs in cardiac arrest patients remains largely unknown.

Purpose of the Study:

  • To investigate the association between circulating microRNA levels and clinical outcomes in cardiac arrest patients.
  • To determine if specific microRNAs can predict neurological outcome and mortality post-cardiac arrest.
  • To compare the predictive value of microRNAs with established biomarkers like neuron-specific enolase.

Main Methods:

  • Prospective, single-center proof-of-concept study involving 28 cardiac arrest patients treated with therapeutic hypothermia.
  • Blood samples collected 48 hours post-cardiac arrest for microRNA and neuron-specific enolase level determination.
  • Neurological outcome assessed using the cerebral performance category at ICU discharge and 6-month follow-up.

Main Results:

  • Two microRNAs, miR-122 and miR-21, were significantly overexpressed in patients with poor neurological outcome.
  • In vitro studies indicated that miR-122 and miR-21 are produced by neuronal cells, suggesting they may reflect brain damage.
  • miR-122 and miR-21 demonstrated moderate predictive accuracy for neurological outcome (AUC 0.73-0.77) and were associated with increased mortality.
  • Neuron-specific enolase showed higher accuracy in predicting outcome (AUC 0.98) and mortality.

Conclusions:

  • Circulating microRNAs (miR-122, miR-21) are modest but significant predictors of neurological outcome and mortality in cardiac arrest patients.
  • Neuron-specific enolase remains a more accurate predictor of outcome and mortality in this cohort.
  • Further validation in larger cohorts is recommended to assess the prognostic value of microRNAs in cardiac arrest.