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Vaccinations

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Related Experiment Video

Updated: May 19, 2026

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

Live (vaccines) from New York.

C J Forlenza¹, T N Small

¹Department of Pediatrics and Clinical Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Bone Marrow Transplantation

|August 15, 2012

Summary

Hematopoietic cell transplantation (HCT) survivors need safe vaccination. This review examines live-attenuated viral vaccines like MMR and varicella vaccines post-HCT.

Area of Science:

Immunology
Transplantation Medicine
Vaccinology

Background:

Over 40,000 hematopoietic cell transplantations (HCT) occur annually worldwide.
Transplant survivors face increased risks from vaccine-preventable diseases like measles, mumps, and varicella.
Current guidelines restrict live-attenuated vaccines post-HCT, limiting options for immunocompromised individuals.

Purpose of the Study:

To review the immunogenicity of measles, mumps, and rubella (MMR) vaccine and live-attenuated varicella vaccine (LAVV) in HCT survivors.
To identify gaps in current data regarding live-attenuated viral vaccine efficacy and safety post-HCT.
To inform vaccination strategies for the growing population of HCT survivors.

Main Methods:

Literature review of published studies on MMR and LAVV immunogenicity in HCT recipients.

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Analysis of current post-HCT vaccination guidelines and contraindications.

Discussion of data limitations and future research needs.

Main Results:

Current data, mainly from pediatric HCT recipients, show 60-70% response rates to single-dose MMR or LAVV.
A two-dose vaccination schedule improves seroconversion rates for these vaccines.
Most live-attenuated vaccines, including shingles vaccines, remain contraindicated post-HCT.

Conclusions:

Further research is needed to establish optimal vaccination schedules and criteria for live-attenuated viral vaccines in HCT survivors.
Safe and effective vaccination is crucial for HCT survivors to prevent infectious disease outbreaks.
Physicians require clear guidance on administering live-attenuated vaccines to this vulnerable population.