Related Experiment Video
Updated: May 19, 2026
Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Comparative study of systemic inflammatory responses in psoriasis vulgaris and mild to moderate allergic contact
1Clinic of Dermatology, University of Tartu, Tartu, Estonia. Sirje.Kaur@kliinikum.ee
Background:
Psoriasis vulgaris (PV) is associated with low-grade systemic inflammation.
Objective:
Cytokines' and growth factors' serum patterns in patients with PV, allergic contact dermatitis (ACD) and healthy subjects were investigated to describe and compare systemic inflammatory responses in these diseases.
Methods:
A total of 12 inflammation-sensitive biomarkers were analyzed simultaneously by means of the Evidence Investigator™ biochip technology.
Results:
In PV, proinflammatory tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukins (IL)-1β, -2, -6, -8, and monocyte chemoattractant protein (MCP)-1 were elevated. In ACD, 2 markers, TNF-α and MCP-1, were increased, and regulatory cytokine IL-10 was decreased. Proinflammatory IL-2 had the strongest correlations with other pro- as well as anti-inflammatory cytokines in PV and ACD, whilst IL-6 correlated positively with the Psoriasis Area and Severity Index. Growth factors' levels correlated with MCP-1, but only in PV.
Conclusion:
Although psoriasis induces a more variegated proinflammatory systemic response, ACD is likewise associated with a systemic increase in inflammatory mediators.
