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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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FDG PET and FDG PET/CT in patients with gastrointestinal stromal tumours

Philipp Malle1, Manfred Sorschag, Hans-Jürgen Gallowitsch

  • 1Department of Nuclear Medicine and Endocrinology, PET-CT Center Klagenfurt, Klinikum Klagenfurt am Wörthersee, Feschnigstraße 11, 9020 Klagenfurt, Austria. philipp.malle@kabeg.at

Wiener Medizinische Wochenschrift (1946)
|August 15, 2012
PubMed

Insights

Positron emission tomography (PET) scans using (18)F-fluorodeoxyglucose (FDG) aid in evaluating gastrointestinal stromal tumours (GISTs). FDG PET/CT imaging is valuable for diagnosis, recurrence detection, and assessing treatment response in GIST patients.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Gastrointestinal stromal tumours (GISTs) are rare malignancies, accounting for <3% of all GISTs.
  • Molecularly targeted therapies, like tyrosine kinase inhibitors, have transformed GIST management.
  • Malignant GISTs exhibit heightened glucose metabolism, leading to increased (18)F-fluorodeoxyglucose (FDG) uptake.

Purpose of the Study:

  • To elucidate the role of FDG PET and FDG PET/CT in GIST diagnosis and management.
  • To highlight the utility of dual-modality imaging for simultaneous functional and anatomical information.
  • To review the impact of FDG PET/CT in initial staging, recurrence detection, and treatment response assessment.

Main Methods:

  • Utilizing (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scans.
  • Employing dual-modality FDG PET/CT imaging for integrated assessment.
  • Reviewing diagnostic and therapeutic applications in GIST patient management.

Main Results:

  • FDG PET/CT provides simultaneous functional and anatomical data crucial for GIST evaluation.
  • The imaging modality is valuable for initial disease assessment and detecting tumour recurrence.
  • FDG PET/CT enables early assessment of treatment response to targeted therapies like imatinib and sunitinib.

Conclusions:

  • FDG PET and FDG PET/CT imaging are integral tools in the comprehensive management of GISTs.
  • These imaging techniques offer significant value in diagnosis, monitoring recurrence, and evaluating therapeutic efficacy.
  • Dual-modality imaging enhances diagnostic accuracy and treatment monitoring for patients with GISTs.

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