Corneal biomechanical properties in children with diabetes mellitus
Necip Kara1, Yusuf Yildirim, Tolga Univar
1Department of Ophthalmology, Kanuni Sultan Suleyman Education and Research Hospital, Istanbul - Turkey.
Insights
This study found that diabetes mellitus does not alter corneal biomechanical properties, specifically corneal hysteresis (CH) and corneal resistance factor (CRF), in children. These measures were also unrelated to diabetic control parameters.
Area of Science:
- Ophthalmology
- Diabetology
- Biomedical Engineering
Background:
- Diabetes mellitus is a systemic disease with potential ocular complications.
- Understanding the impact of diabetes on corneal biomechanics is crucial for comprehensive eye care in pediatric patients.
Purpose of the Study:
- To investigate and compare the corneal biomechanical properties, specifically corneal hysteresis (CH) and corneal resistance factor (CRF), in children with and without diabetes mellitus.
- To assess the correlation between corneal biomechanical parameters and diabetic control indicators in pediatric subjects.
Main Methods:
- A prospective, comparative, cross-sectional study involving 46 children with diabetes mellitus and 50 healthy children.
- Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using the Ocular Response Analyzer.
- Statistical analysis included independent-samples t-tests and correlation analyses.
Main Results:
- No significant differences were observed in mean CH (12.3±1.3 mmHg vs. 12.5±1.5 mmHg) or mean CRF (12.4±1.7 mmHg vs. 11.9±1.5 mmHg) between the diabetic and control groups (p>0.05).
- Corneal hysteresis and CRF showed no significant correlation with fasting glucose levels, HbA1c, age, or duration of diabetes.
Conclusions:
- Pediatric diabetes mellitus does not appear to significantly affect corneal biomechanical properties, including CH and CRF.
- Corneal biomechanical parameters in children are not influenced by glycemic control, age, or the duration of diabetes.
Abstract:
Purpose. To compare the biomechanical properties of corneas in eyes of children with diabetes mellitus and in eyes of children without diabetes mellitus. Methods. In this prospective, comparative, and cross-sectional study, 46 patients with diabetes mellitus (study group) and 50 healthy individuals (control group) were enrolled. The corneal hysteresis (CH) and corneal resistance factor (CRF) were measured in children with and without diabetes using the Ocular Response Analyzer. Differences in the corneal biomechanical properties were determined using an independent-samples t test. Correlations between ocular and diabetic parameters were also evaluated. Results. Mean CH was 12.3±1.3 (SD) mmHg and 12.5±1.5 mmHg and the mean CRF was 12.4±1.7 mmHg and 11.9±1.5 mmHg in the diabetic and control groups, respectively (p>0.05). Corneal hysteresis and CRF were not correlated with fasting glucose level, HbA1c, age, or duration of diabetes. Conclusions. The findings indicate that diabetes mellitus does not affect corneal biomechanical parameters such as CH and CRF in children. In addition, CH and CRF are not affected by fasting glucose level, HbA1c, age, or duration of diabetes.
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