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Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
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Cerebral microvasculature is an early target of subarachnoid hemorrhage

Fatima A Sehba1, Victor Friedrich

  • 1Department of Neurosurgery and Neurosciences, Mount Sinai School of Medicine, New York, NY 10029, USA. fatima.sehba@mssm.edu

Acta Neurochirurgica. Supplement
|August 15, 2012
PubMed

Most subarachnoid hemorrhage (SAH) patients exhibit clinical signs of cerebral ischemia at admission but no angiographic vasospasm. Consequently, the source of early cerebral ischemia is not understood. Parenchymal microvessels may contribute to early cerebral ischemia, but the low resolution of current imaging has prevented their analysis in SAH patients. Animal studies demonstrated that early after SAH structure and function of parenchymal vessels are compromised to the level that may very well contribute to early ischemia. We review these studies.

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