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Updated: May 19, 2026

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
Cochlear abnormality in a case of Pallister-Hall syndrome
Shivaram Avula1, Nusrat Alam, Elaine Roberts
1Department of Radiology, Alder Hey Children's Hospital NHS Foundation Trust, Eaton Road, Liverpool, L12 2AP, UK. shivaram.avula@alderhey.nhs.uk
Abstract:
Pallister-Hall syndrome (PHS) is a rare condition characterised by anomalies including hypothalamic hamartoma, bifid epiglottis and postaxial polydactyly. Hearing loss has been recognised in this condition. Cochlear abnormalities have been described in mouse models of PHS, but there are no reports of similar findings in humans to date. This report describes a case of PHS with bilateral cochlear hypoplasia as seen on MRI.
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