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Aspergilli: systems biology and industrial applications
1Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Biotechnology Journal
|August 15, 2012
Summary
Aspergilli are valuable cell factories for industrial biotechnology. Systems biology approaches, including genome sequencing and metabolic modeling, are now advancing metabolic engineering strategies for these fungi.
Area of Science:
- Biotechnology
- Microbial Engineering
- Systems Biology
Background:
- Aspergilli are widely utilized as cell factories for producing food ingredients, enzymes, and antibiotics.
- Traditional strain improvement relied on random mutagenesis and screening.
- Directed genetic modifications have paved the way for metabolic engineering.
Purpose of the Study:
- To review advancements in Aspergillus systems biology for industrial biotechnology.
- To highlight the impact of systems biology on metabolic engineering of Aspergillus.
- To showcase the application of genome sequencing and metabolic models.
Main Methods:
- Review of scientific literature on Aspergillus systems biology.
- Analysis of genome-wide transcription data.
- Development and application of genome-scale metabolic models.
Main Results:
- Genome sequencing of industrially relevant Aspergillus species is now available.
- Systems biology tools enable advanced metabolic engineering strategies.
- Significant progress has been made in applying these tools to improve Aspergillus cell factories.
Conclusions:
- Aspergillus systems biology is a powerful approach for industrial biotechnology.
- Metabolic engineering of Aspergillus has been significantly advanced by systems biology.
- Future applications hold great promise for optimizing the production of valuable compounds.
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