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Neuroendocrine breast cancer.
Susana Graça1, Joana Esteves, Sílvia Costa
1General Surgery Department, Centro Hospitalar Gaia/Espinho, Gaia, Portugal. sarga3@gmail.com
BMJ Case Reports
|August 15, 2012
Summary
Neuroendocrine breast cancer, a rare malignancy, typically affects older women and has a favorable prognosis. This case highlights a well-differentiated endocrine breast cancer with positive synaptophysin markers, suggesting conservative treatment is often curative.
Area of Science:
- Oncology
- Endocrinology
- Pathology
Background:
- Neuroendocrine breast cancer is a rare malignancy, accounting for approximately 1% of all breast cancers.
- It typically presents as a low-grade, slow-growing tumor, more common in older women.
- Definitive diagnosis relies on immunohistochemical markers such as chromogranin, synaptophysin, or neuron-specific enolase in at least 50% of tumor cells.
