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Ancestral effect on HOMA-IR levels quantitated in an American population of Mexican origin

Hui-Qi Qu¹, Quan Li, Yang Lu

¹The University of Texas School of Public Health, Brownsville Regional Campus, Brownsville, Texas, USA. huiqi.qu@uth.tmc.edu

|August 15, 2012

Abstract

Objective:

An elevated insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) is more commonly seen in the Mexican American population than in European populations. We report quantitative ancestral effects within a Mexican American population, and we correlate ancestral components with HOMA-IR.

Research Design And Methods:

We performed ancestral analysis in 1,551 participants of the Cameron County Hispanic Cohort by genotyping 103 ancestry-informative markers (AIMs). These AIMs allow determination of the percentage (0-100%) ancestry from three major continental populations, i.e., European, African, and Amerindian.

Results:

We observed that predominantly Amerindian ancestral components were associated with increased HOMA-IR (β = 0.124, P = 1.64 × 10(-7)). The correlation was more significant in males (Amerindian β = 0.165, P = 5.08 × 10(-7)) than in females (Amerindian β = 0.079, P = 0.019).

Conclusions:

This unique study design demonstrates how genomic markers for quantitative ancestral information can be used in admixed populations to predict phenotypic traits such as insulin resistance.

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