Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Cellular Adaptation I: Introduction and Atrophy01:23

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing gait parameters with accelerometer-based methods to identify older adults at risk of falls: a systematic review.

European geriatric medicine·2021
Same author

[Frailty in nursing home : contribution of the SENIOR study].

Revue medicale de Liege·2019
Same author

Impact of frailty status on the cost of drugs and dietary supplements prescribed to nursing home residents: the SENIOR cohort.

Aging clinical and experimental research·2019
Same author

Prevalence of sarcopenia in a population of nursing home residents according to their frailty status: results of the SENIOR cohort.

Journal of musculoskeletal & neuronal interactions·2017
Same author

Prevalence of Frailty in Nursing Home Residents According to Various Diagnostic Tools.

The Journal of frailty & aging·2017
Same author

Energy and Nutrient Content of Food Served and Consumed by Nursing Home Residents.

The journal of nutrition, health & aging·2017
Same journal

[Nature prescriptions and health promotion : sharing experience from primary care].

Revue medicale de Liege·2026
Same journal

[Eco-health: shared perspectives on primary care practice].

Revue medicale de Liege·2026
Same journal

[The strategic role of primary care in emerging diseases : surveillance, research, and preparedness].

Revue medicale de Liege·2026
Same journal

[Environmental impact of medicines and approaches for more eco responsible use].

Revue medicale de Liege·2026
Same journal

[Climate change and skin].

Revue medicale de Liege·2026
Same journal

[From Silent Spring to neuronal silence : pesticides and neurodegenerative diseases].

Revue medicale de Liege·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

[Pathological ageing: a myth or reality?].

J Petermans1

  • 1Service de Gériatrie, CHU de Liège, Belgique. jean.petermans@chu.ulg.ac.be

Revue Medicale De Liege
|August 16, 2012
PubMed
Summary
This summary is machine-generated.

Cellular senescence, driven by factors like telomere shortening and oxidative stress, contributes to aging and frailty. Early assessment and interventions like exercise can mitigate its impact on health.

Related Experiment Videos

Last Updated: May 19, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Area of Science:

  • Gerontology and Cellular Biology
  • Molecular mechanisms of aging
  • Physiology of senescence

Background:

  • Senescence is a lifelong process with increasingly understood genetic and biological underpinnings.
  • Replicative senescence is an adaptive process associated with aging.
  • Key factors include telomere length, oxidative stress, and metabolic byproducts.

Purpose of the Study:

  • To explore the biological markers and clinical implications of cellular senescence.
  • To understand the link between senescence, vulnerability, and frailty in the elderly.
  • To discuss potential interventions for managing senescence-related decline.

Main Methods:

  • Review of current research on genetic and biological causes of senescence.
  • Analysis of proposed markers of aging, including telomere length and antioxidant activity.
  • Examination of the physiological and clinical impacts of senescence-related alterations.

Main Results:

  • Telomere length, antioxidant activity, and metabolic accumulation are potential markers of senescence.
  • Senescence contributes to vulnerability and frailty, influencing stress response and phenotypic heterogeneity.
  • Frailty is not irreversible and can be managed through interventions.

Conclusions:

  • Senescence markers are crucial for assessing the clinical status of older individuals.
  • Understanding senescence impacts clinical decisions and therapeutic strategies.
  • Interventions such as physical exercise and nutrition show promise in managing aging and frailty.