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Related Concept Videos

Assessment of the Gastrointestinal System I: Subjective Data01:17

Assessment of the Gastrointestinal System I: Subjective Data

Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
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Assessment of the Gastrointestinal System II: Health Perception Pattern01:29

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Genetics and gastrointestinal symptoms.

Margaret M Heitkemper1, Ruth Kohen, Sang-Eun Jun

  • 1Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, USA.

Annual Review of Nursing Research
|August 16, 2012
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Genetic factors may play a role in irritable bowel syndrome (IBS), a common condition causing abdominal pain and altered bowel habits. Further research is needed to understand the complex genetic influences on IBS development.

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Published on: November 30, 2016

Area of Science:

  • Gastroenterology
  • Genetics
  • Neuroscience

Background:

  • Gastrointestinal (GI) symptoms are common and multifactorial, stemming from GI pathology, diet, infection, stress, and systemic diseases.
  • Irritable bowel syndrome (IBS) is a prevalent condition characterized by altered bowel patterns and abdominal discomfort/pain.
  • Genetic predisposition is suggested by family and twin studies in IBS, but the exact mechanisms remain unclear.

Purpose of the Study:

  • To review the potential role of genetic factors in the etiology of irritable bowel syndrome (IBS).
  • To explore the relevance of specific neurotransmission-related genes to GI symptoms and IBS.

Main Methods:

  • Review of existing literature on genetic factors and IBS.
  • Focus on four genes involved in neurotransmission: serotonin reuptake transporter (SERT), tryptophan hydroxylase (TPH), alpha2-adrenergic receptor (alpha2-ADR), and catechol-o-methyl transferase (COMT).

Main Results:

  • Evidence suggests a role for genetic factors in IBS, though direct associations or indirect influences via environmental interactions are not fully elucidated.
  • A single genetic factor is unlikely to explain IBS due to its multifactorial nature; gene-gene interactions are probable.
  • Four key neurotransmission genes (SERT, TPH, alpha2-ADR, COMT) are discussed for their potential relevance to GI symptoms and IBS.

Conclusions:

  • The genetic contribution to IBS is complex and likely involves multiple genes and their interactions.
  • Further research, including genome-wide association studies with diverse ethnic samples and standardized symptom subgroups, is crucial for a comprehensive understanding of IBS genetics.