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Updated: May 19, 2026
08:26
Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
Nitric oxide delivery by core/shell superparamagnetic nanoparticle vehicles with enhanced biocompatibility
X F Zhang1, S Mansouri, D A Mbeh
1National Research Council of Canada, 75 Boulevard de Mortagne, Boucherville, Québec, Canada J4B 6Y4.
Langmuir : the ACS Journal of Surfaces and Colloids
|August 16, 2012
Summary
We developed novel iron oxide/silica nanoparticles that release nitric oxide (NO) for up to 50 hours. These magnetic nanoparticles enhance biocompatibility and can accumulate inside cells for targeted therapy.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Nitric oxide (NO) plays a crucial role in cellular functions.
- Developing effective delivery systems for NO is challenging.
- Nanoparticles offer potential for targeted drug delivery and enhanced biocompatibility.
Purpose of the Study:
- To synthesize and functionalize Fe(3)O(4)/silica core/shell nanoparticles for nitric oxide (NO) release.
- To investigate the NO release profile and cellular interactions of these functionalized nanoparticles.
- To evaluate the potential of these nanoparticles for targeted NO delivery in biological systems.
Main Methods:
- Synthesis of Fe(3)O(4)/silica core/shell nanoparticles.
- Functionalization of nanoparticles with S-nitrosothiols to enable NO storage.
- Characterization of nanoparticle properties (size, magnetic targeting, NO release).
- Assessment of nanoparticle interaction with human alveolar epithelial cells.
Main Results:
- Successfully synthesized and functionalized Fe(3)O(4)/silica core/shell nanoparticles.
- Demonstrated sustained NO release from nanoparticles for up to 50 hours.
- Showcased magnetic targeting capability for site-specific delivery.
- Observed intracellular accumulation of nanoparticles in human alveolar epithelial cells.
- NO release enhanced nanoparticle biocompatibility.
Conclusions:
- Fe(3)O(4)/silica core/shell nanoparticles functionalized with S-nitrosothiols are effective NO reservoirs.
- These nanoparticles offer a promising platform for targeted, sustained NO delivery.
- The enhanced biocompatibility and intracellular accumulation highlight their therapeutic potential.
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