An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot
Roghayeh Hossein nia1, Manouchehr Mamaghani, Khalil Tabatabaeian
1Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Iran.
Abstract:
Novel fused 1H-benzo[f]chromen-indole derivatives were synthesized regioselectivly in good to high yields by triethyl amine catalyzed condensation of 3-cyanoacetylindoles, β-naphthol and aryl aldehydes in methanol under ultrasounic irradiations and conventional conditions. The easy work-up of the products, rapidity, and mild reaction conditions are notable features of this protocol. The antibacterial activity of the selected products was examined. Some products showed promising activities.
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